منابع مشابه
Systemic Antifungal Agents
Systemic antifungal agents and their use for the therapy of invasive mycoses are discussed in this chapter. Many of these agents can also be used to treat the mucocutaneous forms of candidiasis, but those uses are discussed in detail in Chapter 257 and thus are mentioned only in passing here. Similarly, the therapy of the various forms of tinea and onychomycosis with topical agents or systemic ...
متن کاملAntifungal agents in neonatal systemic candidiasis.
Neonatal systemic candidiasis is increasingly being recognized as a cause of septicemia in the neonatal intensive care unit (2, 19, 26, 36, 59). Predisposing factors for candidemia and subsequently invasive infections include prematurity, prolonged exposure to broad-spectrum antibiotics, the use of intravenous fat emulsions, the presence of necrotizing enterocolitis, prolonged intravascular cat...
متن کاملCurrent concepts in antifungal pharmacology.
The introduction of new antifungal agents (eg, echinocandins, second-generation triazoles) in the past decade has transformed the management of invasive mycoses to the point that drug toxicity is no longer the major limiting factor in treatment. Yet, many of these newer antifungal agents have important limitations in their spectrum of activity, pharmacokinetics, and unique predisposition for ph...
متن کاملAntifungal Agents
Continued advancement of medical science offers life-saving treatment options for a variety of hematologic, oncologic, and rheumatologic conditions. Immunosuppression, a common therapeutic side-effect, predisposes patients to invasive fungal infections, which are escalating in prevalence. The development of effective, welltolerated antifungals has lagged behind the advances of antibacterial the...
متن کاملDENS - Clinical Dental Therapeutics Lecture 4 Pharmacology of Metronidazole and Antifungal Agents
II. The occurrence of modified penicillin-binding sites Modified PBPs have a lower affinity for β-lactam antibiotics, requiring clinically unattainable concentrations of the drug to effect its bactericidal activity Example: penicillin resistance in Streptococcus pneumoniae (pneumococcus) is caused by altered PBPs I. Production of β-lactamases This family of enzymes can inactivate penicillins by...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2006
ISSN: 1537-6591,1058-4838
DOI: 10.1086/504492